Jornal de Toxicologia Clínica
Acesso livre

Abstrato

Quercetin Ameliorated the Alloxan Mediated Hepatic Injury in Diabetic Wistar Rats

Muhammad Aslam

Liver injury is a complex heterogeneous metabolic disorder characterized by chronic hyperglycemia, diabetes, abnormalities in lipid and carbohydrate metabolism. Alloxan an oxidation product of uric acid, 2, 4, 5, 6 (1H, 3H)-pyrimidinetetrone, capable of inducing diabetes by destroying pancreatic tissue and has been widely used for induction of experimental diabetes. Quercetin are flavonoids and has been proved to be effective against pancreatic islets in diabetogenic rats modulating glucose homeostasis, insulin-resistance, oxidative injury and cell death. The present study demonstrated the alloxan induced liver injury and and its protection by quercetin administration in adult male rats. Administration of 130 mg/kg alloxan for 28 days induce diabetes associated liver injury as histomorphological alteration includes vacuolar degeneration of hepatocytes, dilated sinusoids and central vein, and focal hepatocellular necrosis and increased level of liver enzymes serum Alanine Aminotransaminase (ALT), Aspartate Aminotransaminase (AST) and Alkaline Phosphatase (ALP) level of antioxidant enzymes such as Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSHPx) were decreased. Triglycerides, HDL-c, hepatic glycogen, total protein, and body weight were significantly decreased in alloxan induced diabetic rats. However, increased total bilirubin LDL-c, hyperglycemia and hypercholesterolemia were observed. Administration of 150 mg/kg quercetin in alloxan treated rats significantly ameliorated these effects and potentially reversed the liver injury. Hepato-protective mechanism of quercetin was not yet completely understood.