Jornal de Imunologia Clínica e Celular
Acesso livre

Abstrato

Secondary Metabolites of Lichens as Both Anti-aggregative and Antioxidant Agents in Tauopathies

Alberto Cornejo and Carlos Areche

This commentary described our findings of parietin, an anthraquinone, isolated from Ramalina terebrata as inhibitor of tau protein. Moreover, we considered important to link tauopathies with reactive oxygen species since oligomers and fibril-forming elements are responsible for activating reactive oxygen species, which cause inflammatory response and neurodegeneration. Together, we considered important to find naturally occurring compounds that might be able to stop aggregation and reduces ROS cells damage.