Jornal de Imunologia Clínica e Celular
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Abstrato

The Clinical Significance of Both IgM and IgG Anticardiolipin Antibodies in Non-Hodgkins Lymphoma

Manal Mohamed Saber

Background: Anticardiolipin (ACL) antibodies are associated with a wide variety of disorders including malignancies. The aim of this study was to investigate the prevalence and prognostic implication of ACL antibodies in patients with Non-Hodgkin’s lymphoma (NHL).
Methods: Sixty-four patients with NHL were included in this study. Enzyme-linked immunosorbent assay kits were used to measure the concentrations of all IgM and IgG antibodies.
Results: Antibodies (IgM, IgG) were found in 35.9% and 84.3% of patients respectively. The presence of elevated aCl IgM was correlated with relapse in NHL (P<0.001). Pretreatment serum levels of aCL IgG were significantly higher in patients with NHL (P<0.001), and significantly normalized in complete remission. Positive ACL IgG was also found in patients with relapse. A negative correlation was found between aCL antibodies (IgM, IgG) positivity and CD23 (P=0.037, P=0.003) respectively.
Conclusion: Anticardiolipin antibodies are associated with lymphomas. Their determination is useful to predict treatment outcome or disease prognosis.