Jornal Internacional de Medicina Física e Reabilitação
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The Cytokine Regulatory Network of Natural Killer Cells: Involvement in the Regulation of Blood Pressure in Pre-Eclampsia

Jieqi Ke, Yanhuan Zhang, Ting Gao, Weidong Zhao

Natural Killer (NK) cells play an important role in the early development of fetal. Pre-eclampsia is also related to the dysfunction of NK cells in the first trimester of pregnancy. Dysfunction of cytokines secreting in NK cells, including VEGFA, CXCL8, CXCR4, CXCR3 and Growth-Promoting Factors (GPFs) Pleiotrophin (PTN) and Osteoglycin (OGN), promotes the occurrence of pre-eclampsia. And the imbalance of CD158a (KIR2DL1) and CD158b (KIR2DL3) expression on NK cells is correlated with hypertension, while in pre-eclampsia patients CD158a+ NK cells downregulated the expression of ERAP2 and GCH1, which genes are believed to regulate blood pressure. Here we summarize the function of NK cells in pre-eclampsia, including NK cells cytokine regulatory network and function in blood pressure regulation.