Distúrbios Pancreáticos e Terapia
Acesso livre

Abstrato

The Effect of Erythropoietin on Intestinal Damage Developed Secondary to Experimental Acute Pancreatitis

Kahramansoy N, Bozgeyik M, Erkol H, Bozcaarmutlu A, Kukner A and Buyukasik O

Background: In acute pancreatitis, development of intestinal damage is of clinically importance. Such that, preventing the intestinal damage may restrain severity of the pancreatitis. Erythropoietin which has pleiotropic effects is shown to decrease inflammation, the damage of ischemia-reperfusion, and apoptosis in intestine. Here, it is aimed to obtain the effects of erythropoietin on the intestinal damage caused by the acute pancreatitis.

Methods: Twenty one Wistar Albino rats were separated into three (Sham-Control-EPO) groups. Experimental acute pancreatitis was formed by infusion of the 4.5% Na taurocholate into the pancreatic duct. A 1000 U/kg/day dose of erythropoietin was applied in the EPO group, intraperitoneally for three days. The experiment was terminated on the fourth day. Leukocyte in blood, CRP and amylase in serum were studied whereas catalase and glutathione reductase levels were measured in intestinal homogenate as anti oxidant capacity markers.

Results: Among all groups, leukocyte CRP, and amylase levels did not show significant difference. Mean catalase and glutathione reductase levels of the intestinal homogenates were higher in the EPO group rather than the Control group and were close to that of the Sham. Histological damage severity of the intestine was significantly low in the EPO group compared to the Control group (p=0.04).

Conclusion: Erythropoietin prevents the decrease of the catalase and glutathione reductase levels as anti oxidant capacity in the intestine, and protects the intestine against damage, which develops secondarily to the AP.