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The Oncogenic Role of γ-Aminobutyrate Aminotransferase in Human Tumor: A Pan-Cancer Analysis

Xinyu Wang, Yi Jie, Hui Yu, Anqin Dong

Emerging evidence supports the correlation between γ-aminobutyrate aminotransferase (ABAT) and tumors, but few research groups used pan-cancer analysis to verify it previously. Therefore, this study used The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) to obtain information about the correlations between ABAT and tumor development, and to explore its potential effectiveness for genetic alterations in tumor prognosis. The reduced expression level of ABAT in a majority of tumors is significantly associated with the poor prognosis. The genetic alteration of ABAT seems linked to the favorable prognosis of Uterine Corpus Endometrial Carcinoma (UCEC). Immune infiltration analysis showed a significantly positive correlation between ABAT and cancer-associated fibroblasts in the majority of tumors, but a highly negative correlation with Kidney Renal Clear cell carcinoma (KIRC), Kidney Renal Papillary cell carcinoma (KIRP), and Prostate Adenocarcinoma (PRAD). Enrichment analysis showed that cell junction organization, amino acids metabolism, and neuronal system-involved behaviors might affect the pathogenesis or etiology of cancer. This study is the first pan-cancer analysis that offers a detailed, comprehensive study of the process of the oncogenic roles of ABAT across different human tumors.