Jornal de Pesquisa em Dermatologia Clínica e Experimental
Acesso livre

Abstrato

To Evaluate Efficacy and Safety of Low Dose Oral Isotretinoin (20 mg/ Day) Alone Versus Combination of Low Dose Oral Isotretinoin (20 mg/ Day) Plus Topical Tretinoin (0.1%) in Gel Formulation in the Treatment of Verruca Plana

Navneet Kaur Randhawa, Surendra Kumar*, US Agarwal, Puneet Agarwal, Ambika Bansal, Sapna Meena

Background: Plane warts are a common viral infection of skin and mucosa causing significant cosmetic concern to the patient, especially if they are multiple and disseminated over the face.

Objective: To compare the effectiveness and safety of low dose oral isotretinoin (20 mg/day fixed) alone against combination with topical tretinoin (0.1%) in gel formulation for the treatment of verruca plana.

Methods: Two verruca plana treatment approaches were compared in a prospective randomized interventional clinical trial.

Two groups of sixty individuals with numerous plane warts were randomly assigned. Group A received oral isotretinoin capsules at a dose of 20 mg daily, whereas Group B received oral isotretinoin at a dose of 20 mg daily in addition to topical tretinoin 0.1% in gel formulation once daily at night. The patients received treatment for 12 weeks. Patients who had a full recovery were monitored for 8 weeks to track the recurrence rate.

Results: Although the difference was not statistically significant, patients receiving combination therapy had more rapid lesion resolution and a higher total percentage of lesion resolution.

Conclusion: Combination treatment leads to faster and complete resolution of the lesions than oral isotretinoin alone. More trials with large sample size needed.

Limitation: Study sample size was small, that was the only limitation.