Jornal de Oftalmologia Clínica e Experimental
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Translaminar Pressure Gradient in Glaucoma and Non-invasive Methods for Intracranial Pressure Evaluation: A Review

David Andrew Price, Alon Harris and Sunu Mathew

Studies have shown that intracranial pressure is correlated with some ocular diseases including glaucoma, where low intracranial pressure has been found to be correlated with disease progression and high intracranial pressure may play a protective role. Multiple hypothesis have been proposed for the role of intracranial pressure in ocular disease, including that it can act as a stabilizing force to protect the optic nerve from intraocular pressure by balancing forces across the lamina cribrosa. While currently there is no non-invasive measure of intracranial pressure that has consistently performed well across multiple large studies, there are several methods under development which have shown promising results. This paper reviews current understanding of the role of intracranial pressure in ocular diseases, non-invasive methods for measuring intracranial pressure, as well as related topics where current research will likely inform findings on the effect of intracranial pressure on the eye.