Jornal de Proteômica e Bioinformática
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Transmembrane Proteins Function in Cancer Growth and Inhibition

Karolina Sterzynska

The ground-breaking research discovered transmembrane protein as a protein that may contribute to the spread of cancer and demonstrated that blocking it significantly reduced the adhesion and invasion of breast and brain cancer cells by up to 90%. Although several proteins have been identified as having a function in the metastatic process, their structures and modes of action are largely unknown or poorly understood. Nowadys, researchs had predicted that how the transmembrane (TMEM) protein family is involved in the development of metastases or in the processes that cause cancer cells to spread, like migration and extracellular matrix remodelling.