Medicina Interna: Acesso Aberto
Acesso livre

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Treatments against SARS-CoV-2, Current Perspectives: A Review

Minotta Valencia Carlos, Minotta Valencia Lina

This review is intended to provide a comprehensive overview of plausible therapies for SARS-CoV-2. Literature on drugs such as PLpro protease inhibitors, CLpro 3, RNA helicase, and Spike protein is reviewed. Likewise, the efficacy of interferons (innate immunity) and also of monoclonal antibodies (adaptive immunity) is evaluated. In addition, preliminary results on the use of active principles extracted from plants that may have antimicrobial properties are included. A review of the literature is made, which provides data on drugs with potential use to counteract COVID-19, which have been carried out over the course of months, huge in vitro and clinical trials, in controlled and randomized studies, on how positions like Hydroxychloroquine and Chloroquine. Guidelines agreed by medical institutions and advances, findings so far, will also are evaluated.