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Understanding Testosterone Deficiency in Depression: Insights from Cholesterol Dynamics in Leydig Cells of CUMS Mice

Jiaojiao Huang, Zhen Peng, Zhenhua Song*

This study mainly focused on the role of cholesterol dynamics in leydig cells to understanding testosterone deficiency in depression. Numerous studies have demonstrated a link between a higher risk of depression and low testosterone levels. Males with low testosterone frequently experience depressive symptoms and testosterone replacement therapy has been demonstrated to elevate mood in certain testosterone deficient individuals. Meanwhile, depression is frequently associated with hormonal imbalances, including testosterone deficiency. Recent research using chronic unexpected mild stress (CUMS) mice models has uncovered a significant connection between reduced testosterone levels and diminished cholesterol levels in Leydig cells, which are vital for testosterone production. This relationship highlights a significant intersection between mood disorders and metabolic processes.