Distúrbios Imunológicos e Imunoterapia
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Unique COVID/Anti-Spike Protein Immune Responses in Two Elderly Patients without COVID-19 Vaccination

Rocco J. Rotello* , David John Lawhead, Elisha R Injeti, Timothy D Veenstra

Published reports continue to emerge regarding different health outcomes in patients immunized and not immunized against the SARS-CoV-2 antigen (i.e., spike protein) that were infected with the virus. Because of the vast array of protein isoforms made from the laboratory-created SARS-CoV-2 viral genome, patients with different innate immune systems and underlying health issues responded differently upon coronaviruses/cold virus infection and reinfection. The case presentation highlights two patients during the calendar years 2020/21 and 2022, that presented with cold virus symptoms, tested positive for coronavirus antigens on lateral flow strips, developed bacterial sinus infections, were hospitalized, and treated with pooled antibody plasma. Throughout their medical sequela each patient maintained strong antibody titers against spike protein based on IgG levels in their saliva.