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Vitamin D Level and its influence on Systemic Lupus Erythematosus: an overview

Francisco José Navarro-Triviño

Vitamin D plays an important role as an immunomodulator and anti-inflammatory, which is why the role of vitamin D in systemic diseases has generated multiple hypotheses about its role as a possible treatment for some of them. Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune diseases, which involves genetic and environmental factors. Vitamin D deficiency may play a vital role in the pathogenesis and progression of SLE. There are an inverse correlation between serum vitamin D levels and disease activity of SLE. Furthermore, low serum vitamin D levels have been correlated with, fatigue, cardiovascular diseases, anti-ds-DNA cutaneous and renal involvement, and SLE flares. Despite possible controversies between vitamin D deficiency levels and certain aspects of the SLE, what does not raise any doubt is that vitamin D supplementation with regular monitoring should be considered as part of their health management plans. Regardless of whether vitamin D deficiency in patients with SLE is cause or consequence, evaluation of vitamin D status in all SLE patients is essential and mandatory, since vitamin D deficiency has been established as a risk factor for lupus.