Jornal de Proteômica e Bioinformática
Acesso livre

Abstrato

Whether Transcriptome and Proteome Technical Platforms are Intact to Human Genome now ?

Fan Zhong and Fuchu He

Transcriptomic and proteomic technologies are vogues in analyzing biological entities. The integrality of their probe sets or searching databases is the prerequisite of full identification, which could be estimated by their coverages over genome. After the completion of human genome atlas with painstaking effort, expression profiling technology becomes routine analysis in both transcriptome and proteome levels. The mainstream strategies of such profiling, based on expression microarrays and mass spectrum, are enclosed in probe set and sequence database respectively. It is conceivable that their integralities, i.e. their coverages to the whole human genome, determine their capacity in cataloguing transcriptome and proteome.