Sistema Ortopédico e Muscular: Pesquisa Atual
Acesso livre
ISSN: 2161-0533
ISSN: 2161-0533
Rui Zhou* and Anand Pillai
The formation of biofilm is one of the main contributing factors for unsuccessful treatment of osteomyelitis. It is formed through the bacterial adhesion to the fragments of dead bone. Poor perfusion or devascularization of an infected bone with changes in local pH further limits the diffusion of parental antibiotics.
Calcium sulphate, a biocompatible and completely reabsorbable local carrier for antibiotics, has shown promising results in treating osteomyelitis. It is associated with less systemic effect and compliance issues when compared with conventional treatment of surgical debridement and prolonged systemic antibiotics.