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A Novel Research Area of PCDH-PC in Inhibition of Prostate Cancer Cells Invasion and Metastasis through Epithelial: Mesenchymal Transition

Xuezhen Yang1*, Xu Jiang, Xueping Ma, Tomonori Habuchi, Yinglu Guo

Objective: To evaluate the effects of Protocadherin-PC (PCDH-PC) gene expression on Epithelial Mesenchymal Transition (EMT) in prostate cancer cells.

Methods: Western blot analysis, morphological analysis, and in vitro wound closure assay were used to assess the effects of inhibition of PCDH-PC expression on EMT in the androgen-independent prostate cancer cell lines DU- 145 and PC-3.

Results: Inhibition of PCDH-PC expression promoted Mesenchymal Epithelial Transition (MET) of DU-145 and PC-3 cells, which changed the cytomorphology to resemble that of the androgen-dependent prostate adenocarcinoma cells LNCaP, and slowed down the growth rate.

Conclusions: Inhibition of PCDH-PC expression reduced the invasiveness of androgen-independent prostate cancer cells.