Imunoterapia: acesso aberto
Acesso livre

Abstrato

Attention should be paid to the Adverse Reactions of PD-1/PD-L 1 Inhibitors

Peng Wu*, Shulan Lin, Jiao Jiao, Chunyi Li

The adverse reactions caused by using programmed cell death-1/programmed cell death ligand-1(PD-1/PD-L1) inhibitors were evaluated. PD-1 is an immune checkpoint receptor which expresses and activates specific immune cells. When PD-1 binds to immune cells, it will make them useless against cancer cells. PD-1/PD-L1 inhibitor has been an emerging therapy recently and is widely used in cancer patients. PD-1/PD-L1 inhibitor may cause immune imbalance in common cancer patients and organ transplant cancer patients, which may lead to T cells attacking their own organs, causing some adverse reactions against patients, and even endangering their lives.