Bioquímica e Farmacologia: Acesso Aberto
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Biological Evaluation of Products Formed from the Irradiation of Chlorpromazine with a 266 nm Laser Beam

Alexandru T, Armada A, Danko B, Hunyadi A, Militaru A, Boni M, Nastasa V, Martins A, Viveiros M, Pascu ML, Molnar J and Amaral L

Varying concentrations of Chlorpromazine Hydrochloride (CPZ) were exposed to a 266 nm laser beam for varying periods of time ranging from 4 to 24 hrs and the products of irradiation were evaluated for activity against a panel of bacteria that consisted of representatives of Gram-positives and Gram-negatives that expressed different degrees of efflux pump activity, and compared to the parental unexposed compound with prolonged irradiation, whereas the antibacterial activity of the product against Staphylococcus aureus and Escherichia coli strains was many folds greater, no activity against their efflux pumps was noted. The activity of the products of irradiation against Salmonella enterica serovar Enteritidis was slight. However, the products of prolonged irradiation of CPZ produced increasingly significant concentration dependent inhibition of efflux by the Salmonella strains.