ISSN: 2456-3102
Kriti Jain1, Sangeeta Choudhuryand2, Mala Srivastava3, Indrani Ganguli4 and Neha5
The hypothesis of induction of intolerance suggests the role of unique dendritic cell (DC) subsets, NK cells and its ability to prime type 1 regulatory T (Treg) cells in recurrent pregnancy loss (RPL). Thus, we attempted to find if the indices of peripheral Treg/DCs/NK cells and their Th1/2/17 responses can be developed as biomarkers to predict pregnancy loss. Antenatal women with history of RPL (6-20 weeks of singleton pregnancy; n=25), with threatened abortions (TA; 6-20 weeks; n=25), with normal (control) singleton pregnancy (6-12 weeks; n=50), median age of 26±4 yrs were enrolled. Cases with history of chronic diseases/ known anatomical anomalies of womb/genetic or infectious etiology of previous miscarriage were excluded. PBMCs were used to identify dendritic cells as monocytoid and plasmacytoid, co-stimulatory (CD83) and PDL (CD274)