Jornal de Patologia Médica e Cirúrgica
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Comparative Analysis Of Elastic And Collagen Fibers Of Coronary And Carotid Arteries In Autopsied Patients

Luciano Alves Matias da SilveiraI*; Gabriela Ribeiro JulianoII; Laura Sanches AguiarII; Guilherme Ribeiro JulianoII; Bianca Gonçalves Silva TorquatoII; Mariana Silva OliveiraII; Fernando Pimenta de PaulaII; Vicente de Paula Antunes TeixeiraIII; Mara Lúcia da Fonseca FerrazIV

Introduction: Predicting cardiovascular risks is a goal pursued by authors from several research lines in an attempt to demonstrate an association between atherosclerosis in several arterial beds. Objectives: To analyze the morphology of the carotid and coronary arteries of autopsied patients, and to assess the correlation between them. Materials and Methods: For histopathological analysis, 22 autopsy reports were evaluated and 22 sections of the right common carotid artery (RCCA), of the left common carotid artery (LCCA), of the anterior descending coronary artery (ADCA), of the posterior descending coronary artery (PDCA), and of the circumflex coronary artery (Cx) were collected. Leica Qwin Plus® image software was used was used to quantify collagen and elastic fibers. Results: Of the 22 autopsy reports analyzed, 59% of the individuals were male and had a mean age of 45 years. There was no significant difference in the percentages of elastic fibers between the carotid arteries and the different coronary arteries. There was a significant difference in the percentages of collagen fibers only for the Cx artery. Conclusions: The analyses performed show that the onset of atherogenesis is common in different arteries, thus corroborating the literature, which regards it as a systemic inflammatory process affecting several arterial beds. Therefore, studies aiming to predict atherosclerotic risks must be encouraged in order to reduce the morbidity and mortality rates associated with these diseases.