Jornal de Pesquisa Óssea
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Deletion 13q14 in Plasma Cells of a Patient with Lupus Erythematosus and Autoimmune Hepatitis

Sebastian Tuve, Ulrich Sommer, Heike Kostka, Brigitte Mohr, Uta Oelschlägel, Jan Moritz Middeke, Marco Berning, Julia Fantana, Anne Erler, Christiane Jakob, Martin Aringer, Gustavo Baretton, Marc Schmitz, Martin Bornhäuser and Jana Babatz

The molecular mechanisms that lead to autoantibody production and autoimmune disease remain poorly defined. Based on a clinical observation in a patient with lupus erythematosus and autoimmune hepatitis we here provide the first evidence that (i) a particular cytogenetic aberration (deletion (13)(q14)) could be detected in a proportion of plasma cells and that (ii) the surface marker CD56 could be used to enrich for plasma cells with this cytogenetic aberration.