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Different Effects of Lupus IgG on Joint

Guo-Min Deng

Bone destruction is a remarkable feature of inflammatory arthritis. It remains unknown why arthritis associated with systemic lupus erythematosus (SLE) does not result in erosion and destruction. Our recent published paper reports that lupus IgG has different effects on joint tissue, joint deposited lupus IgG induces synovitis but inhibits osteoclastogenesis. Lupus IgG induces synovitis through binding to FcγRI on monocytes/macrophages and inhibits RANKL-induced osteoclastogenesis through competing for FcγRI binding with RANKL. This study enhances the understanding of the pathophysiology of SLE-associated arthritis and provides a protective therapeutic target to against bone destruction in inflammatory arthritis.