Jornal de Nanomedicina e Descoberta Bioterapêutica
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Histology Study of Wistar Rats Implanted With and Without C6 Cells and the Effect of NPt-Cu Nanoparticles

Tessy López, Emma Ortiz Islas, Andrea Morales, José Luis Cuevas, Esteban Gomez, Joaquín Manjarrez, Patricia Guevara, Martha Lilia Tena, Aurora Sánchez, Paolo Lottici, Danilo Bersani, Hugo Monroy and Octavio Novaro

In the present research, we prepare nanoparticles of Cu-TiO2 using different copper precursors with a solgel technique. In these nanobiocatalysts, titania was functionalized on the surfaces with sulfates, fosfates and GABA. We used intracranial glioma the C6 cell method for evaluating the efficiency and toxicity of the glioblastoma multiforme (GBM) tumor. The nanoparticles were tested in four groups of Wistar rats. To wit: 1-reference (normal); 2- C6 cells only; 3- tumor model used with different cooper complexes supported in TiO2. The following subdivision were: 3a- tumor model used with Cu(NH4)2 Cl4 /F-TiO2. 3b-Tumor model used with Cu(Oac)2/F-TiO2. 3c-Tumor model used with Cu(acac)2/F-TiO2. Finally, we add a 3d-titania reference. Immunohistochemical technique shows the following results: less inflammatory response as well as controlled gliosis. In addition a decrease in tumor size in each group.