Biologia celular e do desenvolvimento

Biologia celular e do desenvolvimento
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ISSN: 2168-9296

Abstrato

Impaired Autophagy in Retinal Pigment Epithelial Cells Induced from iPS Cells obtained from a Patient with Sialidosis

Odontuya Davaadorj, Hisako Akatsuka, Yoshiki Yamaguchi, Chisa Okada, Masatoshi Ito, Nahoko Fukunishi, Yoshiki Sekijima, Hideki Ohnota6, Kenji Kawai3, Takahiro Suzuki, Takehito Sato and Yasuyuki Suzuki

Sialidosis type I patient-derived induced pluripotent stem cells (iPSCs) were generated from blood mononuclear cells. During embryoid body-like 3D culture, aggregates of patient-derived iPSCs were irregular in shape and had increased vacuoles filled with lipid droplets and cellular components such as damaged mitochondria. Retinal pigment epithelial cells induced from patient-derived iPSCs showed impaired autophagy flux with decreased formation of LC3 puncta. Sialidosis patient-derived iPSCs could provide a useful tool for investigating the mechanism of the autophagy/ lysosome-mediated degradation system.

Isenção de responsabilidade: Este resumo foi traduzido com recurso a ferramentas de inteligência artificial e ainda não foi revisto ou verificado.
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