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Metformin as an Anticancer Drug: A Commentary on the Potential Therapeutic Strategy and Underlying Mechanism of Metformin in Gastric Cancer

Guanzhen Yu

Metformin therapy is a burst of interest in cancer chemoprevention and therapeutic strategies. Epidemiological studies based on cohorts with type 2 diabetes revealed that metformin usage was associated with a reduced risk for various cancer, including breast, colorectal, prostate and pancreas cancers. Meanwhile, the efficacy of cancer chemopreventive effect of metformin has achieved positive results in multiple target organs, especially, colon and mammary cancer [6]. However, only few epidemiological evidences supported the positive link between type2 diabetes and an increased risk of gastric malignancies.