Jornal de Química Física e Biofísica
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Novel Multivalent Glyco-gold Nanoparticles to Inhibit Bacterial Fim H

Tao Wang Ravikumar Jimmidi Stéphane P. Vincent

The accelerated drug resistance of bacteria is one of the most serious problems in global healthcare and the difficulties in finding new antibiotic drugs are even more challenging. Almost 80% of bacterial infections of living tissues are associated with bacterial biofilms, including lung infections of cystic fibrosis patients, colitis, urethritis, conjunctivitis, otitis, endocarditis and periodontitis.[1] Multivalency is ubiquitous in biological interactions, especially in carbohydrate-mediated processes. The low affinity of carbohydrate-mediated interactions is compensated by clustering of the ligands. However, At the same time, gold nanoparticles have interesting characteristics including a three-dimensional (3D) polyvalent carbohydrate network, a globular shape and a chemically well-defined composition. In this project, we have designed novel multivalent gold nanoparticles with functionalized fullerene-C60, to investigate the inhibition of bacterial Fim H by the gold nanoparticle conjugates.

he worked as a lecturer at the School of Pharmaceutical Engineering of Guizhou Institute of Technology. In 2016, he started his PhD titled “Novel Multivalent Molecules as Antibiofilm and Antibacterial Agents” at the University of Namur under the supervision of Professor Stéphane VINCENT in the research unit of Organic and Bio-organic Supramolecular Chemistry.