Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
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Priming with a GnRH Agonist Before Immature Oocyte Retrieval may Improve Maturity of Oocytes and Outcome in In Vitro Maturation (IVM) Cycle: A Case Report

Anna Smirnova, Margarita Anshina, Einat Shalom Paz, Adrian Ellenbogen*

In the last several years the concept of using a gonadotropin releasing hormone agonist (GnRH-a) for triggering ovulation in patients treated by an antagonist protocol for IVF became almost a routine clinical practice. It may promote oocyte nuclear maturation, resumption of meiosis and cumulus expansion. Several studies reported the retrieval of more mature oocytes after GnRH-a, therefore it seems that this attempt could be beneficial in an in vitro maturation (IVM) oocyte cycle performed for fertility preservation in patients with malignancies but possible for other indication as polycystic ovarian syndrome patients. We presented a case of a patient needed fertility preservation that underwent 3 IVM cycles priming ovulation with a GnRH-a. Twelve oocytes were obtained, all of them matured 4.5 hours after incubation in maturation media. Fertilization rate after ICSI was 10/12 (83%). Six good quality embryos were vitrified. It seems that triggering with a GnRH-a instead of hCG in an IVM cycle could be beneficial in terms of obtaining high grade embryos and possible pregnancy.