Jornal de Distúrbios e Terapia da Tireóide
Acesso livre

Abstrato

Remarkable Effect of Metronomic Chemotherapy in Diffuse Lung Metastases of Thyroid Cancer

Criel M and Geurs F

We present a patient with respiratory insufficiency due to progressive lung metastases of thyroid cancer. Low dose i.v. vinblastin, oral cyclophosphamide and s.c. enoxaparin produced dramatic clinical improvement, a drop in thyroglobulin and prolonged disease stabilisation. This new way of giving classical chemotherapy is called metronomic chemotherapy. Its anti-angiogenic basis of activity is corroborated by the more recent drugs in thyroid cancer which share this mechanism.