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Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)- Quinazolinone Derivatives

Natvar A Sojitra, Rajesh K Patel, Ritu B Dixit and Bharat C Dixit

A series of structurally diverse and newly designed pyrimidinone substituted 4(3H)-Quinazolinone derivatives 6a–6j were synthesized in a simple and facile manner under both conventional and microwave heating conditions. Entitled compounds 6a–6j were synthesized using N-acylanthranilic acid derivatives 1a–1j and hydrazinylbenzenesulfonamide2 as a key starting materials, which under goes hierarchy of the reactions via different intermediate steps; quinazolinone derivatives 3a–3j and hydrazonoquinazolinone derivatives 5a–5j. All the synthesized compounds are in good amount of yield. The structure of entitle compounds have been evaluated on the basis of various spectroscopic techniques and analytical methods as well as, all the synthesized compounds were subjected to in vitro antibacterial activities. Some of the compounds displayed moderate to good in vitro antimicrobial activity by broth micro dilution method against pathogenic bacteria (S. aureus,B. subtilis, B. megaterium, E. coli, P. vulgaris, P. aeruginosa) species.