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Synthesis of Some Novel Fused Heterocyclic Compounds Derivatives from Bis-chalcones

Amira A Ghoneim and Ahmed F El-Farargy

A chalcone was prepared by the reaction of 1,4-diacetylbenzene with benzaldehyde. Reaction of this chalcone with cynanothioacetamide/guanidine hydrochloride and malnonitrile in presence of piperdene afforded the corresponding pyridine, pyrimidine, and pyrans derivatives in good yields respectively. Further, bis-chalcone 1 was cyclized to pyrazole analogs by using thiosemicarbazide, semicarbazide and tertiarybutylcarbazate. The newly heterocyclic compounds have been characterized by IR, 1H-NMR and elemental analyses.