Jornal de Imunologia Clínica e Celular

Jornal de Imunologia Clínica e Celular
Acesso livre

ISSN: 2155-9899

Abstrato

The IgE-Binding Self-Antigens Tubulin-α and HLA-DR-α are Overexpressed in Lesional Skin of Atopic Eczema Patients

Claudio Rhyner, Sabine Zeller, Catharina Johansson, Annika Scheynius and Reto Crameri

Background: Atopic eczema is the most common chronic, relapsing, inflammatory skin disorder with an atopic background. Previous studies have shown that IgE-mediated reactivity to self-antigens plays a role in the pathogenesis of the disease. However, the expression of self-antigens associated with atopic eczema in the lesional skin is poorly investigated.
Aim of the study: This study was aimed to show that IgE-binding self antigens are over-expressed in atopic eczema lesions. Methods: Tubulin-α and HLA-DR-α, two recently described self-antigens, were stained by immunohistochemistry in skin specimens from chronic and acute atopic eczema lesions, unaffected skin from the same patients or skin from healthy controls.
Results: The expression of tubulin-α and HLA-DR-α is up-regulated in atopic eczema lesions compared to nonlesional or healthy skin and correlates with the number of infiltrating immune cells and the degree of inflammation.
Conclusion: Upregulation of IgE-binding self-antigens in lesional skin of atopic eczema patients might further promote the existing inflammation and induce exacerbations of the disease in the absence of exposure to environmental allergens.

Isenção de responsabilidade: Este resumo foi traduzido com recurso a ferramentas de inteligência artificial e ainda não foi revisto ou verificado.
Top