Medicina Interna: Acesso Aberto
Acesso livre
ISSN: 2165-8048
ISSN: 2165-8048
Makwana Rajeshree*
The objective of the resent work was to formulate fast dissolving film of D2 receptor antagonist so as to achieve higher oral bioavailability by minimizing the first pass metabolism and to enhance the compliance by elderly and pediatric patients. D2 receptor antagonist being water insoluble drug pose a challenge in formulating fast dissolving film. So, in order to enhance the solubility solid dispersion were prepared using β-Cyclodextrin as carrier. Polynomial equation was derived and validity of equation was checked by preparing and evaluating check point batches. Surface plots were constructed and desirability of the film was calculated and based on it optimized batch for both plain drug and solid dispersion film was determined. Mechanical properties and drug release was compared between the two films and based on it the best film was finally selected.