Jornal de Toxicologia Clínica
Acesso livre

Abstrato

Antioxidant Effects of Bradykinin Potentiating Factor (BPF) Isolated from Scorpion Venom in Liver Injury Induced by Carbon Tetrachloride (CCl₄) in Male Albino Rats

Muhammad M. A. Salman

The main purpose of this study is to evaluate the ability of bradykinin potentiating factor (BPF) isolated from scorpion venom (Leiurus quinquestriatus) in treatment of liver injuries which induced by injection of CCl₄ in male Albino rats. Male Albino rats (250±20 g body weight) were divided into four groups. In the control group; Albino rats were intraperitoneally (i.p) injected with 100 L saline solution. The second group (i.p) injected with BPF in 100 L saline solutions (1 gm/g. b. w. per 5 days). Third and fourth groups were i.p. injected with 0.5 ml/kg body weight (b. w.) twice weekly of CCl₄ for fifteen days, after that only the fourth group was treated by BPF in 100 μL saline solutions (1 μgm/g. b. w. per 5 days). The results indicated that, CCl₄ injection induced a significant decrease in serum catalase (CAT), Superoxide Dismutase (SOD), reduced glutathione (GSH), total protein and albumin, within thirty days post-injection of CCl₄ as compared to the normal control group. In contrast, CCl₄ induced a significant increase in Malondialdehyde (MDA), Aspartate Amino Transferase (AST), Alanine Amino Transferase (ALT), and Alkaline Phosphatase (ALP) compared to normal control animals. The efficiency of BPF treatment is alleviation the effects of CCl₄ on these parameters. The improvement of these parameters may be attributed to the release antioxidant and cytokines and/or amelioration of the toxic effects of CCl₄ on the liver.