Jornal de Pesquisa em Dermatologia Clínica e Experimental
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Association between the MTHFR 677C/T Polymorphism and Susceptibility to Psoriasis: An Updated Meta-Analysis

Junhua Qi, Yu Zhang, Lvya Zhang, Gang Nie*

The correlation between psoriasis and Methylenetetrahydrofolate Reductase (MTHFR) 677C/T polymorphism has been examined in a number of studies. However, the findings remain ambiguous. The present meta-analysis was conducted to comprehensively evaluate this issue. Eligible studies were searched in EMBASE, PubMed, Web of Science, Wan Fang Database, and Chinese National Knowledge Infrastructure (CNKI) up to December 31, 2021. Pooled Odds Ratios (ORs) with 95% Confidence Intervals (CIs) were calculated to estimate the effects of the MTHFR 677C/T polymorphism on psoriasis risk in different genetic models. Eleven relevant case-control studies were included in our meta-analysis, involving 2010 psoriasis cases and 1881 healthy controls. Pooled analysis suggested that the MTHFR 677C/T polymorphism was associated with increased psoriasis risk in the recessive model (TT vs. TC+CC, OR1.69, 95%CI=1.09-2.61, P=0.020). Stratification by ethnicity indicated that the MTHFR 677C/T polymorphism was associated with increased psoriasis risk in Asians under the recessive model (TT vs. TC+CC, OR=1.64, 95%CI=1.01-2.67, P=0.046) and in Europeans under the allelic model (T vs. C, OR=2.57, 95%CI=1.02- 6.48, P=0.046). In conclusion, the MTHFR 677C/T polymorphism may be associated with an increased psoriasis risk. The TT genotype may increase the risk of psoriasis in Asians. Allele might increase psoriasis risk in Europeans.