Jornal da Síndrome de Down e Anormalidades Cromossômicas
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Casein Kinase 1s Function in Meiosis & Its Impacts

Ivan Kanev

Casein kinase 1 (CK1) is a protein kinase that belongs to the serine/threonine family. CK1 members, which are present in all eukaryotes, play a role in the regulation of various cellular processes such as cell cycle initiation, spindle dynamics, and chromosome segregation. Furthermore, CK1 regulates essential signalling pathways such as Wnt (Wingless/Int-1) and Hh (Hedgehog), which are considered to be crucial in tumour progression. Given the role of CK1 in correct cell division and tumour suppressor activity control, it is not shocking that scientific effort has skyrocketed. CK1 controls the transition from interphase to metaphase in mitosis in mammals. CK1 phosphorylates Rec8 subunits of the cohesin complex in budding yeast and fission yeast, regulating chromosome segregation during meiosis. Two cycles of chromosome division accompany a single cycle of DNA replication in meiosis, resulting in haploid gametes from diploid precursors. Any chromosome segregation error may lead to aneuploidy, which is one of the most prevalent causes of miscarriage, abortion, and a number of genetic diseases in humans. The expression and biological function of CK1 family members, especially their role in meiosis, are summarised in this study.