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Dihydromyricetin Induces Apoptosis by Reducing TGF-β via P53 Activation in HepG2 Cells

Liu B, Lian T, Hao S, Jia K, Lu C, Du Feng, Shiting Bao and Runzhi Zhu

Di-hydromyricetin extracted from the stems and leaves of Ampelopsis grossedentata is a bioactive flavonoid compound. It exhibits antithrombotic anti-inflammatory and anticancer activity according to our previous research. Di-hydromyricetin could induce human hepatocellular carcinoma cells apoptosis. In our study we demonstrated that DHM could significantly inhibit HepG2 cells proliferation and induce HepG2 cells apoptosis by flow cytometry and MTT methods. Furthermore, we found DHM could regulate TGF-β signal pathway (P53 SMAD3 and P-SMAD2/3) proteins. Moreover, we confirmed that the antitumour activity of DHM was regulated through the activation of p53 (MDM2 P-MDM2 BAX and Bcl-2). Our findings defined that DHM could induce HepG2 cells apoptosis by reducing TGF-β via p53 pathway.