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Effect of Preoperative Pregabalin on Induced Hypotension and Postoperative Analgesia with Functional Endoscopic Sinus Surgery

Hesham Mohamed Marouf, Naglaa Khalil Khalil

Background: Our target was to estimate the effect of pregabalin as premedication on deliberate hypotension and quality of the surgical site during functional endoscopic surgery for nasal sinuses (FESS) and its postoperative analgesic effect.
Materials and methods: Eighty patients ASA I-II prepared for FESS were included in this randomized research. The study encompassed 2 groups [control group (C) and pregabalin group (P)]. Patients were given either placebo capsule [group (C)] or pregabalin capsule 150 mg [group (P)] 1 h preoperatively. During surgery mean arterial blood pressure (MAP) was maintained between 55-60 mmHg by intravenous infusion of nitroglycerin (NTG) at a rate of 0.5-10 μg/kg/min. We recorded quality of surgical site [using average category scale (ACS)], the overall dose of NTG used, postoperative pain, the overall dose of morphine used postoperatively, and number of patients requesting analgesia.
Results: Pregabalin group (P) showed better ACS, lower overall dose of NTG used, less postoperative pain, lower overall dose of morphine, and less number of patients requesting analgesia than control group (C).
Conclusion: Preoperative oral pregabalin improved the quality of the surgical site during FESS, and decreased the required dose of intraoperative hypotensive agent and postoperative morphine with better postoperative analgesia.