Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Acesso livre

Abstrato

Influence of Elevated LH: FSH Ratio on IVF Outcome, Comparing the Impacts of Different Triggering Medicines

Zakwan Khrait

Objective: To study how elevated LH: FSH ratio influence IVF outcome in High response patients with different triggering medicines.
Design: This study was observational study performed in Medcare Fertility Centre, Dubai, UAE, between April 2016 to July 2017. Patients: 81 high ovarian response women (AMH ≥ 4 ng/ml and LH/FSH ≥ 1).
Main outcome: Measures the impact of high LH/FSH ratioo on IVF outcome in according to the triggering used.
Results: The LH/FSH ratio (when less than 1.5) has significant effect (p<0.05) on the total number of M2 oocytes and subsequently on the fertilization rates (IVF outcome) but no significant (p>0.05) effect on the number of total retrieved oocytes. But as LH/FSH ratio increases further (>1.5), all parameters significantly decreased. Furthermore, patients using uhcg (Pregnyl®) recorded higher number of matured oocytes retrieved (81%) and improves fertility rate (66%) while GnRHa (Gonapeptyl.01®) has better effectiveness (114%) only on the total number of oocytes retrieved and it has less rate of oocytes maturation comparable to uhcg (74% vs. 81%). Conclusion: This study observed that for high response patients, with LH/FSH ratio less than 1.5 has significant effect on total matured oocytes retrieved and subsequently the fertilization when we use of uhcg (Pregnyl®) as ovulation triggering medicine improves IVF outcome. Also, noted that when LH/FSH ratio more than 1.5, baseline characteristics parameters began to significantly decrease to find the triggering with GnRHa (Gonapeptyl.01®) proved to be better in the number of Oocytes retrieved and maturation rate of oocytes.