Bioquímica e Farmacologia: Acesso Aberto
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SMAC Mimetics: Promising Therapeutic Agents in Cancer and other Diseases

Laurence Dubrez

Smac mimetics are a very promising new class of anticancer agents demonstrating an acceptable safety profile and efficacy in some preclinical models of cancers when used as a single agent or in combination with conventional or nonconventional therapies. Future preclinical and clinical trials could enlarge their spectral of action in inflammatory, fibrotic and infectious diseases.