Jornal da Síndrome de Down e Anormalidades Cromossômicas
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Sole Translocation (6;9)(p23;q34) in AML-ETO Negative AML-M2 Patient

Pina J Trivedi, Dharmesh M Patel, Priya Varma, Manisha M Brahmbhatt and Prabhudas S Patel

Acute myeloid leukemia (AML) is a heterogeneous group of disorders with regards to its pathology and molecular genetics features. Translocation (6;9)(p23;q34) is a cytogenetic aberration that can be found in specific subtypes of both AML and myelodysplastic syndrome. This translocation is associated with an unfavorable prognosis. The t(6;9) is found in myeloproliferative disorders with typical clinical characteristics. This translocation results in highly consistent abnormalities at the molecular level. Here, we describe a case of sole translocation (6;9)(p23;q34) in AML-ETO negative AML-M2 patient with conventional cytogenetic and Fluorescence In Situ Hybridization (FISH) study results.