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Synthesis of Four New Brassinosteroids Analogues 11-Oxo-Functionalized on C Ring, with 24-Nor Side Chain and Containing 5β-Cholanic Acid Skeleton

Luis Espinoza

In this work, I report the synthesis of four new brassinosteroids analogues with 24-nor side chain and 11-oxo functionalized on C ring, containing 5β-cholanic acid skeleton: 3α, 12β-diacetoxy-22(S), 23-dihydroxy-24-nor-5β-cholan- 11-one (20); 3α, 12β, 22(S), 23-tetrahydroxy-24-nor-5β-cholan-11-one (21); 3α, 12β, 22(S), 23-tetraacetoxy-24-nor-5β- cholan-11-one (22) and 3α, 12β-diacetoxy-[2,2-dimethyl-22(S), 23-dioxolane]-24-nor-5β-cholan-11-one (23) derivatives from commercial deoxycholic acid.