Endocrinologia e Síndrome Metabólica
Acesso livre

Abstrato

Utilization of extracellular vesicles for treatment of Type 1 Diabetes Mellitus (T1DM) along with 2 T2DM besides complications associated with diabetes

Kulvinder Kochar Kaur

We have earlier reviewed both etiopathogenesis along with therapy of both type1 Diabetes Mellitus (DM) (T1D) as well as( T2D) thoroughly along with advances in therapy. Despite that there is no permanent cure and with the growing epidemic of obesity and thus the parallel enhancement of worldwide prevalence. Extra cellular vesicles(ECV) by definition are physiologically bilayered vesicles that carry bioactive receptors, lipids , proteins as well as nucleic acids which cross-react with target cells, driving the modification of target cells. Maximum cells liberate ECV as well as recently have been shown to not only work as promising biomarkers for disease but work as therapeutic agents for some diseases. ECV represent a heterogenous population of small membrane vesicles (30-2000nm) liberated from various types of activated or apoptotic cells. In view of their ability of carrying out cell-cell communication, lot of significance has been given to them regarding their role as biomarkers or as utilization for therapy by trying to overtake cell based therapy.