Genômica e biologia de fungos
Acesso livre

Abstrato

Current use of Antifungal Eye Drops and How to Improve Therapeutic Aspects in Keratomycosis

Anxo Fernandez-Ferreiro, Miguel González-Barcia, Gil Martínez M, Blanco Méndez J, FJ Otero-Espinar, F Ferreiro A, Victoria Díaz Tome and MJ Lamas

Background: Fungal keratitis is a disease that has a low prevalence and poor outcome because of its minimal therapeutic spectrum.
Objective: The purpose of the current study is to provide an overview of the use of antifungal topical eye drops in a third level hospital and to highlight possible improvements that can optimize their therapeutic use.
Methods: Fungal keratitis cases treated in the Ophthalmology Department of a Tertiary hospital were reviewed in a four-year retrospective study.
Results: For four years, 24 patients received an antifungal eye drop treatment for fungal keratitis: 20% were treated with topical fluconazole and 80% were treated with topical voriconazole (79% in monotherapy and 21% in conjunction with topical natamycin). In most cases, fungal growth was been detected and susceptibility was rarely reported, facilitating the realization of directed treatment towards the most frequently isolated fungi (Fusarium, Candida, Paecilomyces).
Conclusion: In a disease with low prevalence and complicated management, we have detected improvement in the three involved departments: ophthalmology, pharmacy and microbiology.