Bioquímica e Farmacologia: Acesso Aberto
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Abstrato

The Effect of Extracts of Citrus Sinensis Peel on Protoscolices in Echinococcus Granulosus.

Fadel Y S Al-Arabi*, Gozif Mohammed N Omer, Mansour Abdulnabi H Mahdi, Nahad MS Fartwt, Mazahar Farooqui, Vidya Pradhan

The present study aims to evaluate the scolicidals effects of Citrus sinensis peel extract on the protoscolices of hydatid cysts on an in vitro and in vivo. Protoscolices were aseptically aspirated from the livers of naturally infected sheep. Various concentrations of extract were used for 1-24h. Eosin exclusion test was used to determine the viability of protoscolices. Findings showed that extract at the concentrations of 100, mg/mL killed 100% protoscolices after 6 hour , but the concentration 75 and 50 mg/mL killed the protoscolices after 12 hours and 24 exposure, respectively. Obtained results in this investigation for demonstrated that sweet orange might be a natural source for the production of new scolicidals agents.